Epithalon

Epithalon (also known as Epitalon or Epithalone) is the synthetic version of the polypeptide Epithalamin which is naturally produced in the pineal gland.

It was discovered by the Russian scientist Professor Vladimir Khavinson, who then conducted epitalon-related research for the next 35 years in both animal and human clinical trials.

Epitalon’s primary role is to increase the natural production of telomerase, a natural enzyme that helps cells reproduce telomeres, which are the protective parts of our DNA. This allows the replication of our DNA so the body can grow new cells and rejuvenate old ones. Younger people produce a relatively large amount of telomerase and longer telomeres. The longer the telomere strands are, the better cell health and replication they provide. However, as people age, the production of telomerase falls and consequently cell replication and health decline. This is the main reason that people age.

It also plays a role in regulating metabolism, increasing the sensitivity of hypothalamus to its natural hormonal influences, normalizing the function of the anterior pituitary and regulating the levels of gonadotropins and melatonin in the body.

Benefits of Epitalon:

As a result of Epitalon’s effect on telomerase production, the benefits are unique and far-reaching and include:

  • An increase of human lifespan by lengthening telomeres in human cells
  • Promotion of deeper sleep
  • Delay and prevention of age-related diseases such as cancer, heart disease, and dementia
  • Acts as an anti-oxidant by reducing lipid oxidation and ROS (Reactive oxygen species) along with normalizing T cell function.
  • Improvement of skin health and appearance
  • Healing of injured and deteriorating muscle cells
  • Restores and normalizes melatonin levels in older people who have lost some pineal function due to aging
  • Can increases resistance to emotional stress

Research:

  • Anisimov, V.N., Khavinson, V.K. (2009). The use of peptide bioregulators for cancer prevention: results of 35 years of research experience and perspectives. Voprosy Onkologii [Russia]. 55(3):291-304.
  • Bartsch, C. & Bartsch, H. (2000). Pineal gland and cancer – An epigenetic approach to the control of malignancy: Evaluation of the role of melatonin. Madame Curie Bioscience Database [Internet]. Austin (TX): Landes Bioscience; 2000-.
  • Christensen, K., Thinggaarda, M., McGue, M., Rexbye, H., Hjelmborg, J.B., Aviv, A., … Vaupel, J.W. (2009). Perceived age as a clinically useful biomarker of aging: cohort study. Bio Medical Journal (online). 339:b5262.
  • Dilman, V. M., Dean, W., Fowkes, S. W., & Dilman, V. M. (1992). The neuroendocrine theory of aging and degenerative disease.Pensacola, FL: Center for Bio-Gerontology.
  • Khavinson., V.K. (2002). Peptides and aging. Neuroendocrinology Letters [ special issue]. p. 144.
  • Khavinson, V.K., Bondarev, E., Butyugov, A.A. (2003). Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bulleting of Experimental Builogy and Medicine. 135(6): 590-592.
  • Khavinson, V.K., & Morozov, V. (2003). Peptides of pineal gland and thymus prolong human life. Neuroendocrinology Letters. 24:233-240.
  • Korkushko, O.V., Khavinson, V.K., Shatilo, V.B., Magdich, L.V. (2004). Effect of peptide preparation epithalamin on circadian rhythm on epiphyseal melatonin-producing function in elderly people. Bulletin of Experimental Biology and Medicine [Russia]. 137(4): 127-146.
  • Labunets., I.F., Butenko, G.M., Magdich, L.V., Korkushko, O.V., Khavinson, V.K., Shatilo, V.B. (2004). Effect of epithalamin on circadian relationship between the endocrine function of the thymus and melatonin-producing function of the pineal gland in elderly people. Bulletin of Experimental and Biological Medicine [Russia]. 137(5):617-619.
  • Terry, D.F., Nolan, V.G., Andersen, S.L., Perls, T.T., Cawthon, R. (2008). Association of longer telomeres with better health in centenarians. The Journals of Gerontology Series A, Biological and Medical Sciences. 63(8): 809-812.

Conclusion:

Numerous studies have shown the importance of telomerase production and telomere rejuvenation in fighting the symptoms of aging. As Epitalon has been shown to increase the production of telomerase which in turn strengthens and lengthens telomeres, this means that Epitalon can play a vital role in decreasing the aging process and thus extend human longevity.